Smooth Muscle Biomechanics
Our current research in smooth muscle biomechanics represents a
collaborative effort between the departments of Mechanical Engineering,
Biochemistry, Pediatrics and Surgery at VCU. Our work is focused on the
characterization and modeling of the complex mechanical behavior of
smooth muscle and the identification of the physiological mechanisms
responsible for this behavior. More specifically, we are characterizing
strain softening and adjustable passive stiffness in bladder tissue and
developing a new mechanical model for adjustable passive stiffness in
smooth muscle. We have recently expanded the scope of our work to
include vascular and airway smooth muscles. The significance of this
research lies in its potential to provide insight into the
physiological mechanisms that affect smooth muscle stiffness and
contractile activity, and their potential role in disorders, such as
hypertension, asthma and urinary incontinence.